ALDACTONE 25MG TABS 20S

ALDACTONE 25 mg Tablets (20 tablets)
Active Ingredient: Spironolactone 25 mg
Therapeutic Class: Potassium-Sparing Diuretic / Aldosterone Antagonist

Indications:

ALDACTONE is indicated for the treatment of:

• Edema associated with congestive heart failure, liver cirrhosis, or nephrotic syndrome

• Hypertension (high blood pressure), alone or in combination with other antihypertensives

• Primary hyperaldosteronism (diagnosis and treatment)

• Hypokalemia (low potassium), especially when other diuretics cause potassium loss

• Heart failure (NYHA class III-IV) to reduce morbidity and mortality

Mechanism of Action:

Spironolactone is an aldosterone antagonist. It acts on the distal renal tubules to inhibit sodium reabsorption and potassium excretion, resulting in a diuretic effect while conserving potassium.

Dosage and Administration:

• Edema/Hypertension: 25–100 mg daily in single or divided doses

• Heart failure: Typically 25 mg once daily (may be adjusted based on serum potassium)

• Primary hyperaldosteronism: 100–400 mg/day

• Dose should be individualized based on clinical condition and renal function

Warnings and Precautions:

• Monitor serum potassium and renal function regularly

• Risk of hyperkalemia, especially in patients with kidney dysfunction or when combined with other potassium-sparing agents

• Use cautiously in elderly or diabetic patients

• Contraindicated in patients with anuria, acute renal insufficiency, or hyperkalemia

Side Effects:

• Common: Hyperkalemia, gynecomastia, breast tenderness, dizziness, gastrointestinal upset

• Rare but serious: Severe hyperkalemia, renal dysfunction, allergic reactions

Storage:

Store at room temperature (below 30°C) in a dry place. Protect from moisture and light. Keep out of reach of children.