TWYNSTA 80MG/5MG 28 TAB

 TWYNSTA 80 mg / 5 mg Tablets (28 Tablets)
Active Ingredients:

• Telmisartan 80 mg – Angiotensin II Receptor Blocker (ARB)

• Amlodipine Besylate 5 mg – Calcium Channel Blocker (Dihydropyridine class)
  Therapeutic Class: Antihypertensive combination
  Dosage Form: Oral tablet

Indications:

TWYNSTA is indicated for the treatment of:

• Essential hypertension in adult patients whose blood pressure is not adequately controlled by telmisartan or amlodipine monotherapy

• Cardiovascular risk reduction in patients at risk of heart disease with high blood pressure

Mechanism of Action:

• Telmisartan blocks the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and aldosterone release, thus lowering blood pressure

• Amlodipine inhibits calcium ion influx into vascular smooth muscle, causing vasodilation and reduced peripheral resistance

Together, they provide a synergistic blood pressure-lowering effect by acting on complementary mechanisms.

Dosage and Administration:

• Recommended dose: One tablet once daily

• Should be taken at the same time each day, with or without food

• Not recommended as initial therapy — indicated when monotherapy is insufficient

Warnings and Precautions:

• Contraindicated in pregnancy (especially 2nd and 3rd trimesters)

• Caution in patients with renal or hepatic impairment, heart failure, or volume depletion

• Monitor blood pressure, renal function, and electrolytes during treatment

Side Effects:

Common: dizziness, peripheral edema, flushing, fatigue, hypotension
Less common: back pain, increased heart rate, nausea, rash, elevated potassium

Storage:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.