LOTENSE 10mg 30 CAPS

LOTENSE 10 mg Capsules (30 capsules)
Active Ingredient: Enalapril Maleate 10 mg
Therapeutic Class: Angiotensin-Converting Enzyme (ACE) Inhibitor
Dosage Form: Oral capsules

Indications:

LOTENSE is indicated for the treatment of:

• Hypertension (high blood pressure) – to lower blood pressure and reduce the risk of cardiovascular events such as stroke and heart attack

• Heart failure – as adjunctive therapy to improve symptoms and reduce hospitalizations

• Asymptomatic left ventricular dysfunction – to prevent the progression to overt heart failure

Mechanism of Action:

Enalapril is an ACE inhibitor that reduces the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to vasodilation, reduced aldosterone secretion, decreased blood pressure, and improved cardiac function.

Dosage and Administration:

• Hypertension: Typical starting dose is 5–10 mg once daily. Maintenance dose: 10–20 mg/day in one or two doses

• Heart failure: Start with 2.5 mg daily, then titrate upward as tolerated

• May be taken with or without food

• Dosage should be adjusted in patients with renal impairment

Warnings and Precautions:

• Contraindicated in pregnancy, history of angioedema related to ACE inhibitors, and bilateral renal artery stenosis

• Monitor serum potassium, renal function, and blood pressure

• Use with caution in patients with volume depletion, renal impairment, or diabetes

• Risk of angioedema, especially in Black patients

Side Effects:

Common: dry cough, dizziness, fatigue, headache, hypotension
Less common but serious: angioedema, renal dysfunction, hyperkalemia

Storage:

Store below 30°C in a dry place. Protect from moisture and light. Keep out of reach of children.