INEGY 10MG/40MG 28S

INEGY 10 mg / 40 mg Tablets (28 tablets)

Active Ingredients:

• Ezetimibe 10 mg

• Simvastatin 40 mg

Therapeutic Class:
Lipid-Lowering Agent – Combination of Cholesterol Absorption Inhibitor and HMG-CoA Reductase Inhibitor (Statin)

Indications:
INEGY is indicated for:

• The treatment of primary hypercholesterolemia (heterozygous familial and non-familial) and mixed hyperlipidemia

• Homozygous familial hypercholesterolemia (HoFH), in combination with other lipid-lowering treatments

• Patients not adequately controlled with statin therapy alone
  It reduces total cholesterol, LDL-C, ApoB, and triglycerides while increasing HDL-C.

Mechanism of Action:
Ezetimibe inhibits the absorption of cholesterol in the small intestine, while Simvastatin inhibits cholesterol synthesis in the liver. Their complementary mechanisms provide a synergistic lipid-lowering effect.

Dosage and Administration:
One tablet once daily, in the evening, with or without food.
Patients should follow a cholesterol-lowering diet.
Dose adjustment may be needed in patients with renal impairment or when used with interacting medications.

Warnings and Precautions:

• Contraindicated in active liver disease or persistent elevations in liver enzymes

• Avoid use during pregnancy and breastfeeding

• Monitor liver function and creatine kinase (CK) if muscle symptoms occur

Side Effects:
Common side effects include headache, abdominal pain, myalgia, fatigue, and elevated liver enzymes. Rare but serious effects include rhabdomyolysis and liver injury.

Storage:
Store below 30°C. Protect from light and moisture. Keep out of reach of children.