GLUCOVANCE 500/2.5 30tab

 Glucovance 500 mg / 2.5 mg Tablets
Active Ingredients: Metformin Hydrochloride 500 mg, Glibenclamide 2.5 mg
Pack Size: 30 Tablets
Therapeutic Class: Oral Antidiabetic – Biguanide + Sulfonylurea Combination

Description:
Glucovance combines two antidiabetic agents: metformin (a biguanide) and glibenclamide (a sulfonylurea), used to manage blood glucose in patients with type 2 diabetes mellitus. Metformin decreases hepatic glucose production and enhances insulin sensitivity, while glibenclamide stimulates insulin secretion from the pancreas.

Indications:

• For the treatment of type 2 diabetes mellitus in adults when diet, exercise, and monotherapy with either metformin or glibenclamide do not provide adequate glycemic control.

Dosage and Administration:

• Starting dose: Usually one tablet once or twice daily with meals to reduce gastrointestinal side effects.

• Dosage should be individualized based on blood glucose response.

• Do not exceed the maximum recommended daily dose (usually 2000 mg metformin / 20 mg glibenclamide).

• Tablets should be swallowed whole with water.

Contraindications:

• Type 1 diabetes mellitus

• Diabetic ketoacidosis

• Moderate to severe renal or hepatic impairment

• Known hypersensitivity to sulfonylureas, metformin, or any tablet component

• Pregnancy and lactation

Warnings and Precautions:

• Risk of lactic acidosis from metformin, especially with impaired renal function

• Risk of hypoglycemia, particularly in elderly or those with irregular meals

• Monitor blood glucose and renal function regularly

• Use caution with alcohol intake

Possible Side Effects:

• Hypoglycemia

• Nausea, vomiting, or diarrhea

• Headache

• Weight gain

• Allergic skin reactions

Storage:
Store below 25°C in a dry place, away from moisture and direct light.